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Estructura de un homólogo bacteriano de la vitamina K, la epoxida reductasa

Weikai Li1, Sol Schulman, Rachel J Dutton

  • 1Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA. weikai@crystal.harvard.edu

Nature
|January 30, 2010
PubMed
Resumen

Determinamos la estructura cristalina de una enzima bacteriana llamada vitamina K epóxido reductasa (VKOR). Esto revela cómo VKOR utiliza electrones para activar la vitamina K, afectando la coagulación de la sangre y la resistencia a los anticoagulantes de la warfarina.

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