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In ovo Expression of MicroRNA in Ventral Chick Midbrain
Published on: September 16, 2013
Los microARN de animales antiguos y la evolución de la identidad tisular
Foteini Christodoulou1, Florian Raible, Raju Tomer
1Developmental Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
Nature
|February 2, 2010
Resumen
Los antiguos microARN (miRNA) evolucionaron junto con la complejidad del plan corporal en animales bilaterales. Los primeros miARN estaban activos en tipos celulares específicos, revelando los tejidos ancestrales del antepasado del protostomo-deuterostomo.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología evolutiva Biología evolutiva.
- Genética La genética.
Sus antecedentes:
- La evolución de los animales bilaterales está marcada por una creciente complejidad, paralela a un aumento en el número de microARN (miRNA).
- Los microARN juegan un papel crucial en la regulación y el desarrollo de los genes.
Objetivo del estudio:
- Para investigar los antiguos sitios de actividad de las familias de miRNA bilaterales conservadas.
- Comprender el vínculo entre la evolución temprana del miRNA y el desarrollo de los planes corporales.
Principales métodos:
- Análisis comparativo de patrones de expresión de miARN bilaterales conservados.
- El estudio de la expresión de miRNA en Platynereis dumerilii (protostoma), Capitella (annelida), Strongylocentrotus (deuterostoma) y Nematostella (grupo externo).
Principales resultados:
- El miRNA animal más antiguo, miR-100, y los miRNAs relacionados (miR-125, let-7) se expresaron inicialmente en células neurosecretoras alrededor de la boca.
- Otros miARN antiguos se encontraron en células ciliadas locomotoras, centros cerebrales o sistemas de órganos principales (SNC, sensorial, musculatura, intestino).
Conclusiones:
- La evolución del microARN y el establecimiento de la identidad tisular estuvieron estrechamente acoplados durante la evolución bilateral.
- El estudio describe un conjunto mínimo de tipos celulares y tejidos presentes en el antepasado común de los protostomas y deuterostomas.
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