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Live Dissection of Drosophila Embryos: Streamlined Methods for Screening Mutant Collections by Antibody Staining
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La cinta adhesiva para los cromosomas rotos
1Cell Cycle & Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. gjg@omrf.org
Cell
|February 10, 2010
Resumen
Durante la división celular, los tethers de cromatina evitan que los fragmentos de cromosomas que carecen de centrómeros causen errores catastróficos en los neuroblastos de la mosca de la fruta. Este descubrimiento pone de relieve un nuevo mecanismo para mantener la estabilidad genómica durante la mitosis.
Área de la Ciencia:
- Biología celular Biología celular.
- Genética La genética.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La mitosis es un proceso crítico de división celular esencial para el crecimiento y la reparación.
- Las rupturas de doble cadena de ADN durante la mitosis representan una amenaza significativa para la integridad genómica.
- Los fragmentos cromosómicos sin un centrómero no pueden ser segregados correctamente, lo que lleva a la aneuploidía.
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