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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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Síntesis enantioselectiva de sistemas de anillos 1-azabicíclicos sustituidos angularmente: resolución cinética

Tatsuya Ito1, Larry E Overman, Jocelyn Wang

  • 1Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, California 92697-2025, USA.

Journal of the American Chemical Society
|February 24, 2010
PubMed
Resumen

Una nueva síntesis enantioselectiva proporciona aminas 1-azabicíclicas sustituidas angularmente con alto rendimiento y 99% de exceso enantiomérico (ee). Este método utiliza una estrategia de resolución cinética dinámica única para una síntesis estereoselectiva eficiente.

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