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La actividad elevada de la ATPasa de KaiC aplica un punto de control circadiano en la división celular en el
Guogang Dong1, Qiong Yang, Qiang Wang
1Center for Biological Clocks Research, Department of Biology, Texas A&M University, College Station, 77843-3258, USA.
Cell
|February 25, 2010
Resumen
El reloj circadiano de las cianobacterias regula la división celular mediante la regulación de la formación de anillos FtsZ. La proteína clave del reloj KaiC
Área de la Ciencia:
- Biología circadiana Biología circadiana.
- Regulación del ciclo celular Regulación del ciclo celular
- Fisiología microbiana fisiología microbiana.
Sus antecedentes:
- Los relojes circadianos coordinan los ritmos diarios en la fisiología y el comportamiento.
- El ciclo celular está vinculado al reloj circadiano en algunos organismos.
- Se desconoce el mecanismo por el cual el reloj circadiano cianobacteriano abre las puertas de la división celular.
Objetivo del estudio:
- Para investigar el mecanismo de las puertas circadianas de la división celular en Synechococcus elongatus.
- Para identificar los componentes del reloj involucrados en la regulación de la citocinesis.
Principales métodos:
- Microscopia de lapso de tiempo del tipo silvestre Synechococcus elongatus.
- Análisis de los componentes clave del reloj circadiano, incluidas las proteínas KaiC y KaiA.
Principales resultados:
- El control de la división celular se confirmó en el tipo silvestre de Synechococcus elongatus.
- Un estado específico de la proteína KaiC, vinculado a la actividad de la ATPasa, inhibe la formación de anillos FtsZ.
- Se descubrió una nueva actividad que estimula la fosforilación de KaiC independientemente de KaiA.
Conclusiones:
- El reloj circadiano abre las puertas de la división celular en el Synechococcus elongatus a través de la inhibición de la formación de anillos FtsZ.
- La actividad de la ATPasa y la fosforilación de KaiC desempeñan funciones distintas en el control de la división celular y los comportamientos circadianos.
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