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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Síntesis total asimétrica de la vindolina

Daisuke Kato1, Yoshikazu Sasaki, Dale L Boger

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|March 2, 2010
PubMed
Resumen

Este estudio detalla una síntesis total asimétrica concisa de (-) -vindolina utilizando una cascada de cicloadición en tándem. Un sustituto quiral controla la estereoquímica, construyendo eficientemente el núcleo pentacíclico y su funcionalidad en un solo paso.

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