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Impactos del tamaño de las nanopartículas de sílice mesoporosa, el ordenamiento de los poros y la integridad de los
Yu-Shen Lin1, Christy L Haynes
1Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.
Journal of the American Chemical Society
|March 17, 2010
Resumen
Las nanopartículas porosas de sílice exhiben toxicidad dependiente del tamaño, pero solo cuando su estructura de poros está intacta. La integridad de los poros comprometida aumenta la hemólisis, mientras que el recubrimiento PEG la elimina.
Área de la Ciencia:
- Toxicología de nanomateriales.
- La biocompatibilidad de las nanopartículas de sílice.
- Las interacciones entre células y nanopartículas.
Sus antecedentes:
- Las nanopartículas de sílice (SiNPs) son ampliamente utilizadas, lo que requiere una evaluación de toxicidad.
- La comprensión de las interacciones entre las nanopartículas y las células es crucial para una aplicación segura.
- La hemólisis es un indicador clave del daño de la membrana de los glóbulos rojos.
Objetivo del estudio:
- Para evaluar la toxicidad de las nanopartículas de sílice porosas y no porosas.
- Para investigar la influencia de la estructura y la integridad de los poros en la toxicidad.
- Para determinar el papel de la química superficial en la hemólisis inducida por nanopartículas.
Principales métodos:
- Prueba de hemólisis para medir el daño de los glóbulos rojos.
- Variando el tamaño de las nanopartículas, la porosidad y la modificación de la superficie.
- Caracterización de la estructura de las nanopartículas y la integridad de los poros (TEM, XRD, adsorción-desorción N2).
Principales resultados:
- Tanto los SiNPs porosos como los no porosos causaron hemólisis dependiente de la concentración y el tamaño.
- La hemólisis dependiente del tamaño se observó solo para los SiNP mesoporosos con poros ordenados.
- Los SiNP porosos mostraron una menor actividad hemolítica que los no porosos.
- La integridad de los poros comprometida aumentó la hemólisis; el recubrimiento PEG lo eliminó.
Conclusiones:
- La estructura y la integridad de los poros son factores críticos en la toxicidad de las nanopartículas de sílice.
- La química de la superficie, específicamente los grupos silanol, influye en la actividad hemolítica.
- La modificación de la superficie con PEG puede mitigar la hemólisis inducida por nanopartículas.
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