Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Overview of Cell Death01:30

Overview of Cell Death

7.7K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.7K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.2K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.2K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

3.9K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
3.9K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.4K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.4K
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

70
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
70
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

99
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
99

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Metabolic control of autophagy.

Cell·2014
Same author

A phase I/II trial of Erlotinib in higher risk myelodysplastic syndromes and acute myeloid leukemia after azacitidine failure.

Leukemia research·2014
Same author

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

Autophagy·2014
Same author

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Nature medicine·2014
Same author

Entosis, a key player in cancer cell competition.

Cell research·2014
Same author

Cytokines reinstate NK cell-mediated cancer immunosurveillance.

The Journal of clinical investigation·2014

Video Experimental Relacionado

Updated: May 5, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

7.9K

Decodificación de las señales de muerte celular en la inflamación y la inmunidad.

Laurence Zitvogel1, Oliver Kepp, Guido Kroemer

  • 1INSERM, Villejuif, France. zitvogel@igr.fr

Cell
|March 23, 2010
PubMed
Resumen

El daño celular expone las moléculas superficiales que envían señales al sistema inmunológico. Las combinaciones de estas señales dictan cómo se eliminan las células moribundas y dan forma a la respuesta inmune resultante.

Más Videos Relacionados

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.2K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.6K

Videos de Experimentos Relacionados

Last Updated: May 5, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

7.9K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.2K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.6K

Área de la Ciencia:

  • Inmunología Inmunología.
  • Biología celular Biología celular.
  • La señalización molecular.

Sus antecedentes:

  • Las células moribundas (apoptosis) liberan señales moleculares.
  • Estas señales interactúan con el sistema inmunológico.
  • Las señales específicas y sus combinaciones no se comprenden completamente.

Objetivo del estudio:

  • Para investigar cómo las señales moleculares de las células moribundas influyen en las respuestas inmunes.
  • Para explorar el papel de las combinaciones de señales en las vías de envolvimiento celular.

Principales métodos:

  • Análisis de marcadores moleculares en la superficie de las células apoptóticas.
  • Ensayos in vitro para evaluar las interacciones de las células inmunes con las células moribundas.
  • Investigando las vías de fagocitosis.

Principales resultados:

  • Identificó patrones moleculares específicos expuestos en las células moribundas.
  • Demostró que distintas combinaciones moleculares se correlacionan con diferentes mecanismos de engulfment.
  • Se demostró que estas combinaciones modulan el tipo y la intensidad de la activación de las células inmunes.

Conclusiones:

  • Las firmas moleculares en las células moribundas son determinantes críticos de la vigilancia inmune.
  • La señalización combinatoria regula tanto la limpieza de los desechos celulares como la posterior respuesta inmune adaptativa.
  • La comprensión de estas señales puede ofrecer objetivos terapéuticos para la modulación inmune.