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NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
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Hacia las relaciones de flexibilidad-actividad por espectroscopia de RMN: dinámica de los ligandos Pin1

Andrew T Namanja1, Xiaodong J Wang, Bailing Xu

  • 1University of Notre Dame, Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, USA.

Journal of the American Chemical Society
|April 2, 2010
PubMed
Resumen

La relajación del espín de la Resonancia Magnética Nuclear (RMN) revela cómo la flexibilidad de los ligandos afecta la actividad biológica. Este método guía la rigidificación estratégica de ligandos para mejorar el diseño de fármacos mediante el establecimiento de relaciones de flexibilidad-actividad (FAR).

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