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La sincronía de las entradas talamocorticales maximiza la confiabilidad cortical
Hsi-Ping Wang1, Donald Spencer, Jean-Marc Fellous
1Howard Hughes Medical Institute, Computational Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037, USA. ping@salk.edu
Science (New York, N.Y.)
|April 3, 2010
Resumen
Las entradas tálamicas sincrónicas impulsan de manera confiable las neuronas de la corteza visual. El flujo óptimo de información en la corteza depende de la excitación y la inhibición equilibradas, lo que sugiere que la sincronia de picos es clave para la función cortical.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neurociencia computacional es una neurociencia computacional.
- La neurociencia de sistemas es la neurociencia de sistemas.
Sus antecedentes:
- Las entradas del tálamo influyen significativamente en las neuronas de la corteza visual primaria (V1).
- A pesar de su fuerte influencia, las sinapsis tálamicas representan una pequeña fracción (~5%) de las sinapsis totales en la capa 4 de células estelares espinosas.
Objetivo del estudio:
- Para modelar las entradas excitatorias e inhibidoras de alimentación hacia adelante a las células estelares espinosas de la capa 4 de V1.
- Para investigar la relación entre las entradas talamicas sincrónicas y la fiabilidad de la transmisión de picos.
- Explorar el papel del equilibrio entre la excitación cortical y la inhibición en el control del flujo de información.
Principales métodos:
- Se utilizaron grabaciones in vivo de la corteza visual primaria del gato.
- Desarrolló modelos computacionales de las entradas sinápticas feedforward.
- Analizó la confiabilidad de la transmisión de picos en función del número y el tiempo de entrada talamática síncrona.
Principales resultados:
- La confiabilidad de la transmisión de picos aumentó drásticamente con 20-40 entradas tálamicas sincrónicas dentro de una ventana de 5 milisegundos.
- La máxima eficiencia energética para la transmisión de picos se produjo dentro de este rango óptimo de sincronización.
- El equilibrio entre la excitación cortical de fondo y la inhibición moduló el rango óptimo de las entradas sincrónicas.
Conclusiones:
- Las entradas talamicas sincrónicas son cruciales para una transmisión de picos confiable en V1.1.
- El equilibrio cortical excitación-inhibición actúa como un guardián para el flujo de información.
- La sincronía de picos neuronales en poblaciones pequeñas puede representar un principio general para el procesamiento eficiente de la información cortical.
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