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Generación de un nuevo patrón de color de ala por el morfogén sin alas
Thomas Werner1, Shigeyuki Koshikawa, Thomas M Williams
1Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA.
Nature
|April 9, 2010
Resumen
El morfógeno sin alas genera complejas manchas en las alas de Drosophila guttifera. Este intrincado patrón evolucionó de diseños más simples mediante la adición de nuevos sitios de expresión sin alas, un proceso probablemente común en la coloración animal.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología evolutiva Biología evolutiva.
- Coloración de los animales.
Sus antecedentes:
- Los patrones de color de los animales son cruciales para el comportamiento y la ecología.
- Los mecanismos de la formación y evolución del patrón de color son poco conocidos.
- El patrón de alas manchadas de Drosophila guttifera presenta un modelo para estudiar el desarrollo del patrón.
Objetivo del estudio:
- Investigar los mecanismos de desarrollo subyacentes al patrón de alas manchadas de Drosophila guttifera.
- Para explorar las vías evolutivas que condujeron al complejo patrón de manchas.
- Para determinar el papel del morfógeno sin alas en la generación de patrones.
Principales métodos:
- Análisis de los patrones de expresión génica durante el desarrollo de las alas.
- Manipulación genética para estudiar la función del morfogén sin alas.
- Análisis comparativo de los patrones de alas entre especies relacionadas.
Principales resultados:
- Las manchas de las alas en Drosophila guttifera son inducidas por el morfógeno sin alas.
- Los sitios de expresión sin alas se determinan por información posicional preexistente.
- El complejo patrón de manchas evolucionó a través de la cooptación de la expresión sin alas en nuevos sitios.
- El proceso evolutivo implica la superposición de nuevos patrones en marcos de desarrollo preexistentes.
Conclusiones:
- El morfógeno sin alas es un factor clave en la generación del patrón de alas manchadas de Drosophila guttifera.
- La evolución de patrones complejos puede ocurrir a través de la adición gradual de nuevas señales de desarrollo.
- Este mecanismo de evolución de patrones por "estratificación" puede estar muy extendido en el reino animal.
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