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Intravascular Delivery of Biologics to the Rat Kidney
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Published on: September 1, 2016

Enfermedad renal ateroembólica.

Francesco Scolari1, Pietro Ravani

  • 1Faculty of Medicine, University of Brescia, Brescia, Italy. fscolar@tin.it

Lancet (London, England)
|April 13, 2010
PubMed
Resumen

La enfermedad renal ateroembólica, causada por cristales de colesterol que bloquean las arterias renales, tiene un mal pronóstico. La prevención y el tratamiento sintomático, incluidas las estatinas, son clave, y los esteroides pueden ayudar en casos graves.

Área de la Ciencia:

  • Nefrología Nefrología.
  • Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
  • Patología Patología Patología.

Sus antecedentes:

  • La enfermedad renal ateroembólica es el resultado de la ruptura de la placa ateromatosa y la embolización de cristales de colesterol en las arterias renales.
  • La embolización puede afectar a múltiples órganos, incluida la piel, el tracto gastrointestinal y el cerebro, complicando el diagnóstico.
  • La condición a menudo surge después de procedimientos vasculares o anticoagulación, aunque ocurren casos espontáneos.

Objetivo del estudio:

  • Para resumir la fisiopatología, el diagnóstico, el pronóstico y el manejo de la enfermedad renal ateroembólica.
  • Para resaltar los desafíos de diagnóstico y las características clínicas clave.
  • Para esbozar las estrategias terapéuticas actuales y potenciales.

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Principales métodos:

  • Revisión de la literatura existente sobre la enfermedad renal ateroembólica.
  • Análisis de los criterios de diagnóstico, incluida la presentación clínica y los hallazgos de apoyo.
  • Evaluación de las modalidades de tratamiento y factores de pronóstico.

Principales resultados:

  • La tríada diagnóstica clásica incluye un evento precipitante, insuficiencia renal aguda / subaguda y lesiones cutáneas.
  • Los cristales de eosinophilia y colesterol en la circulación retiniana apoyan el diagnóstico, a menudo confirmado por biopsia.
  • El pronóstico tanto para la función renal como para la supervivencia del paciente es generalmente pobre.

Conclusiones:

  • El reconocimiento temprano y la evitación de los factores precipitantes son cruciales para la prevención.
  • El manejo sintomático de la hipertensión, la insuficiencia cardíaca y renal es esencial.
  • Las estatinas se recomiendan para la estabilización de la placa; los esteroides pueden beneficiar a los casos inflamatorios.