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Videos de Conceptos Relacionados

Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Los liposomas permanecen intactos cuando se complejan con cepillos policatiónicos.

Alexander A Yaroslavov1, Andrei V Sybachin, Marc Schrinner

  • 1Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russian Federation. yaroslav@libro.genebee.msu.ru

Journal of the American Chemical Society
|April 15, 2010
PubMed
Resumen
Este resumen es generado por máquina.

Los liposomas aniónicos fueron inmovilizados en partículas de polímero catiónico. Estos contenedores auto-organizados conservan sus propiedades para potenciales aplicaciones biomédicas.

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Área de la Ciencia:

  • Ciencia de los materiales y nanotecnología.
  • Ingeniería Biomédica Ingeniería Biomédica.
  • Química de Polímeros La Química de Polímeros es la química de los polímeros.

Sus antecedentes:

  • Los liposomas son vehículos versátiles para la administración de fármacos.
  • La modificación de la superficie de los polímeros es crucial para aplicaciones avanzadas.
  • La inmovilización controlada de las nanoestructuras es un área de investigación activa.

Objetivo del estudio:

  • Para investigar la adsorción de liposomas aniónicos en partículas de polímero catiónico.
  • Para caracterizar los liposomas inmovilizados y sus propiedades.
  • Explorar el potencial de estas estructuras en campos biomédicos.

Principales métodos:

  • Síntesis de partículas de polímero esférico con macromoléculas catiónicas injertadas.
  • Adsorción de liposomas aniónicos en las superficies funcionalizadas del polímero.
  • Caracterización del tamaño, la forma y la eficiencia de encapsulación de los liposomas utilizando técnicas como la dispersión dinámica de la luz y la microscopía.

Principales resultados:

  • Los liposomas aniónicos se adsorben con éxito en las superficies de partículas de polímero catiónico.
  • El tamaño y la forma de los liposomas se mantuvieron sin cambios después de la adsorción.
  • La capacidad de encapsulación de los liposomas se conservó tras la inmovilización.
  • Formación de contenedores estables, inmovilizados y auto-organizados.

Conclusiones:

  • El estudio demuestra un método para crear sistemas liposomales inmovilizados en soportes de polímero.
  • Estos liposomas inmovilizados mantienen su integridad estructural y funcionalidad.
  • El sistema desarrollado es prometedor para aplicaciones en la administración de medicamentos y diagnósticos.