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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Neural Circuits01:25

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
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Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...

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Clasificación de patrones olfativos por estados discretos de la red neuronal.

Jörn Niessing1, Rainer W Friedrich

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstr. 66, CH-4058 Basel, Switzerland.

Nature
|April 16, 2010
PubMed
Resumen

El cerebro clasifica la entrada sensorial en representaciones discretas cambiando los estados de actividad neuronal. Los estudios de los bulbos olfativos del pez cebra muestran transiciones olfativas abruptas, no cambios graduales, que apoyan este cálculo cerebral.

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Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • Investigación del sistema olfativo de investigación del sistema olfativo.
  • El procesamiento sensorial es el procesamiento sensorial.

Sus antecedentes:

  • El cerebro clasifica la información sensorial en representaciones discretas, cruciales para la cognición y el comportamiento.
  • Los circuitos neuronales pueden lograr la clasificación de patrones a través del cambio abrupto de estado, aunque la evidencia experimental es limitada.

Objetivo del estudio:

  • Investigar si los circuitos neuronales cambian entre estados de actividad discretos para clasificar la entrada sensorial.
  • Para probar modelos de atracción de la computación neuronal en el bulbo olfativo.

Principales métodos:

  • Medición óptica de las respuestas neuronales de salida del bulbo olfativo del pez cebra.
  • Variación gradual de la concentración del olorante y la identidad molecular.
  • Análisis de los patrones de actividad de la población y coordinación del conjunto neuronal.

Principales resultados:

  • Los patrones de actividad de la población de bulbos olfativos fueron robustos a los cambios en la concentración de olorantes.
  • Las transiciones abruptas en las representaciones neuronales ocurrieron cuando un olor se transformó en otro.
  • Estas transiciones implicaron cambios coordinados en pequeños conjuntos neuronales, no cambios de estado de la red global.

Conclusiones:

  • El bulbo olfativo clasifica la entrada evocada por el olor en patrones de salida discretos, alineándose con los modelos de atractor.
  • Este mecanismo de clasificación discreto apoya los fenómenos perceptivos y puede ser una estrategia general del cerebro.