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El inicio del comportamiento colectivo en las amebas sociales
Thomas Gregor1, Koichi Fujimoto, Noritaka Masaki
1Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.
Science (New York, N.Y.)
|April 24, 2010
Resumen
En el Dictyostelium discoideum, se encuentra la adenosina cíclica 3 3 .
Área de la Ciencia:
- Biología celular Biología celular.
- Biología del desarrollo Biología del desarrollo.
- El comportamiento de las amebas sociales.
Sus antecedentes:
- La señalización periódica extracelular cíclica de adenosina 3',5'-monofosfato (cAMP) impulsa la agregación de Dictyostelium discoideum y la formación de cuerpos frutales.
- El origen de estas oscilaciones de la cAMP (celular intrínseco frente al nivel de la población) sigue sin estar claro.
Objetivo del estudio:
- Investigar si las oscilaciones cAMP en Dictyostelium discoideum son una propiedad celular intrínseca o un fenómeno a nivel de población.
- Para determinar el papel del comportamiento de las células individuales en el inicio de la señalización colectiva de cAMP.
Principales métodos:
- Imágenes de células vivas de las poblaciones intactas de Dictyostelium discoideum.
- Experimentos en cámaras de perfusión con células aisladas y poblaciones celulares.
- Análisis cuantitativo del pulso celular y la concentración de cAMP.
Principales resultados:
- Los pulsos de cAMP en poblaciones intactas se originan en un lugar específico, a pesar del intercambio celular.
- Tanto las células individuales aisladas como las poblaciones exhiben actividad rítmica dependiente de la concentración de cAMP extracelular.
- El pulso estocástico de células individuales por debajo de una concentración umbral es crítico para iniciar el comportamiento colectivo.
Conclusiones:
- Dictyostelium discoideum las oscilaciones cAMP surgen de una combinación de propiedades celulares intrínsecas y dinámicas a nivel de población.
- La estocasticidad celular individual juega un papel clave en el surgimiento del comportamiento multicelular coordinado.
- Comprender estas dinámicas proporciona información sobre la señalización del desarrollo y la migración celular colectiva.
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