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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

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Video Experimental Relacionado

Updated: Jun 13, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Descifrando el código de empalme.

Yoseph Barash1, John A Calarco, Weijun Gao

  • 1Biomedical Engineering, Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto M5S 3G4, Canada.

Nature
|May 7, 2010
PubMed
Resumen
Este resumen es generado por máquina.

Los científicos desarrollaron un código de empalme utilizando características de ARN para predecir el empalme alternativo específico del tejido. Este código revela nuevos patrones de empalme y mecanismos reguladores, ayudando a la investigación de enfermedades.

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Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Using the E1A Minigene Tool to Study mRNA Splicing Changes

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • La genómica es la genómica.
  • La bioinformática es la bioinformática.

Sus antecedentes:

  • El empalme alternativo es vital para la complejidad biológica.
  • La mala regulación del empalme alternativo está relacionada con enfermedades humanas.

Objetivo del estudio:

  • Para armar un "código de empalme" predictivo para el empalme alternativo dependiente de los tejidos.
  • Para identificar nuevos patrones de empalme y programas regulatorios.
  • Para descubrir secuencias reguladoras verificadas por mutación.

Principales métodos:

  • Desarrollo de un modelo computacional ("código de empalme").
  • Análisis de cientos de características de ARN para predecir el empalme de exones.
  • Análisis de todo el genoma de eventos alternativos de empalme.

Principales resultados:

  • El código predice el empalme alternativo específico del tejido para miles de exones.
  • Se identificaron nuevas clases de patrones de empalme y distintos programas regulatorios específicos de los tejidos.
  • Reveló estrategias regulatorias generalizadas, incluidas las características intrónicas y la modulación de la estructura de transcripción.
  • Descubrieron exones que silencian la expresión en adultos a través de la descomposición mediada por el disparate, pero promueven la expresión durante la embriogénesis.

Conclusiones:

  • El "código de empalme" proporciona una poderosa herramienta para comprender la regulación alternativa de empalme.
  • Facilita el descubrimiento y la caracterización de eventos de empalme alternativos regulados en todo el genoma.
  • Ofrece información sobre el papel del empalme alternativo en el desarrollo y la enfermedad.