Videos de Experimentos Relacionados
Altas dosis anuales de vitamina D oral y caídas y fracturas en mujeres mayores: un ensayo controlado aleatorizado
Kerrie M Sanders1, Amanda L Stuart, Elizabeth J Williamson
1Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Victoria, Australia 3220. kerrie@barwonhealth.org.au
JAMA
|May 13, 2010
Resumen
La suplementación anual de dosis altas de vitamina D en mujeres mayores no redujo las caídas o fracturas y puede aumentar el riesgo. Este estudio investigó la eficacia de una sola dosis anual de colecalciferol para la prevención de caídas y fracturas.
Área de la Ciencia:
- Gerontología Gerontología.
- Ciencias de la Nutrición Ciencias de la Nutrición
- Salud ósea Salud ósea.
Sus antecedentes:
- El estado de la vitamina D es un factor de riesgo modificable para caídas y fracturas en adultos mayores.
- La adherencia a la suplementación diaria de vitamina D a menudo es pobre.
- Las dosis anuales altas de vitamina D pueden ofrecer una estrategia de suplementación alternativa.
Objetivo del estudio:
- Evaluar si una dosis oral anual única de 500.000 UI de colecalciferol mejora la adherencia y reduce las caídas y fracturas en mujeres mayores.
- Evaluar el impacto de dosis altas de vitamina D en la incidencia de caídas y fracturas en una población de alto riesgo.
Principales métodos:
- Un ensayo doble ciego controlado con placebo de 3 a 5 años en el que participaron 2256 mujeres mayores de 70 años con alto riesgo de fractura.
- Los participantes recibieron 500.000 UI de colecalciferol o placebo anualmente.
- Las caídas y las fracturas se monitorearon a través de calendarios mensuales y se confirmaron radiológicamente; un subestudio evaluó los niveles de vitamina D.
Principales resultados:
- El grupo de colecalciferol experimentó una mayor incidencia de caídas (RR 1.15) y fracturas (RR 1.26) en comparación con el placebo.
- Un patrón temporal mostró un mayor riesgo de caídas dentro de los 3 meses posteriores a la dosis.
- Los niveles de vitamina D aumentaron significativamente después de la suplementación, pero no confirieron efectos protectores contra caídas o fracturas.
Conclusiones:
- La administración oral anual de dosis altas de colecalciferol en mujeres mayores aumentó el riesgo de caídas y fracturas.
- Esta estrategia de suplementación puede no ser efectiva para prevenir caídas y fracturas en este grupo demográfico.
- Se necesita más investigación para determinar las estrategias óptimas de dosificación de vitamina D para la prevención de caídas y fracturas.
Videos de Conceptos Relacionados
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:15Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:23Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
01:21Skeleton and Calcium Homeostasis
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.