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Propiedades estructurales y comportamiento dinámico de los oligómeros no fibrilares formados por PrP ((106-126))

Patrick Walsh1, Philipp Neudecker, Simon Sharpe

  • 1Molecular Structure and Function Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

Journal of the American Chemical Society
|May 15, 2010
PubMed
Resumen

Los oligómeros no fibrilares, implicados en enfermedades neurodegenerativas, comparten elementos estructurales con las fibrillas amiloides pero exhiben un trastorno y movilidad distintos. Comprender estos agregados de proteínas es clave para diferenciar sus actividades biológicas.

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