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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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El cobre cataliza la propargilación asimétrica de los aldehídos

Daniel R Fandrick1, Keith R Fandrick, Jonathan T Reeves

  • 1Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877-0368, USA. daniel.fandrick@boehringer-ingelheim.com

Journal of the American Chemical Society
|May 21, 2010
PubMed
Resumen

La catálisis del cobre permite la propargillación asimétrica de aldehídos utilizando un reactivo de propargilo borolano. Este método logra una alta selectividad para varios aldehídos, creando valiosos intermedios quirales para una mayor síntesis.

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