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Published on: August 2, 2012
Compartimentos hidrofóbicos coexistentes a través de la autoclasificación en micelas en forma de varilla de bisurea
Asish Pal1, S Karthikeyan, Rint P Sijbesma
1Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Journal of the American Chemical Society
|May 21, 2010
Resumen
Los investigadores crearon compartimentos hidrofóbicos separados en el agua utilizando bolaamphiphiles autoclasificados. Diferentes bolaanfifilos formaron distintas poblaciones de micelas, que se unen selectivamente a sondas fluorescentes específicas, lo que demuestra un autoensamblaje molecular controlado.
Área de la Ciencia:
- Química supramolecular de las moléculas.
- Ciencia de los materiales Ciencia de los materiales.
- Colloide y la química de las superficies.
Sus antecedentes:
- Controlar la formación de dominios hidrofóbicos distintos dentro de las soluciones acuosas es un desafío.
- Los bolamfífilos, moléculas con cabezas hidrófilas en ambos extremos de una cadena hidrofóbica, ofrecen potencial para el autoensamblaje.
- La autoclasificación molecular es una estrategia para crear complejas estructuras autoensambladas a partir de mezclas.
Objetivo del estudio:
- Para investigar la formación de múltiples compartimentos hidrofóbicos coexistentes en el agua.
- Para explorar el comportamiento de auto-clasificación de bolaamphiphiles con diferentes espaciados de grupo de urea hidrofóbica.
- Para demostrar las capacidades de unión selectiva de estos compartimentos autoensamblados.
Principales métodos:
- Síntesis de bolaanfifilos con diferentes grupos de urea espaciados en sus segmentos hidrofóbicos.
- Preparación de mezclas de estos bolaanfifilos en soluciones acuosas para inducir la autoclasificación.
- Utilizando sondas fluorescentes funcionales de bisurea para la incorporación y detección selectiva de huéspedes.
Principales resultados:
- Se crearon con éxito múltiples compartimentos hidrofóbicos coexistentes dentro de una sola solución acuosa.
- Demostró que diferentes bolaamphiphiles se auto-clasifican en distintas poblaciones de micelas tipo varilla.
- Se mostró la unión selectiva de las sondas fluorescentes a sus poblaciones de micelas bolaamphiphiles correspondientes.
Conclusiones:
- La autoclasificación molecular de los bolaanfifilos proporciona una ruta para diseñar microambientes hidrofóbicos coexistentes en el agua.
- Las distintas poblaciones de micelas exhiben un reconocimiento selectivo de los huéspedes, lo que permite la compartimentación.
- Este trabajo ofrece una plataforma para el desarrollo de materiales funcionales avanzados y sistemas químicos controlados en medios acuosos.
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