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Las funciones opuestas de la calcineurina y el ATF3 en el cáncer de piel escamosa

Xunwei Wu1, Bach-Cuc Nguyen, Piotr Dziunycz

  • 1Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.

Nature
|May 21, 2010
PubMed
Resumen

Los inhibidores de la calcineurina aumentan el riesgo de carcinoma de células escamosas (CCS). La supresión de la señalización de calcineurina / NFAT promueve la formación de tumores en la piel al inhibir la senescencia dependiente de p53, con ATF3 desempeñando un papel clave.

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