Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

476
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
Glomerular Filtration01:15

Glomerular Filtration

4.7K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
4.7K
Renal Corpuscle01:20

Renal Corpuscle

6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

19.9K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
19.9K
Nephrons01:10

Nephrons

6.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.0K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor.

Nature communications·2026
Same author

Molecular crowding effects on protein stability in a bacterial proteome.

Scientific reports·2026
Same author

Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.

Molecular aspects of medicine·2025
Same author

Mycobacterium tuberculosis triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1.

PLoS pathogens·2025
Same author

Selective RNA sequestration in biomolecular condensates directs cell fate transitions.

Nature biotechnology·2025
Same author

Integrative multi-omics analysis <i>in vivo</i> identifies influenza virus host factors.

iScience·2025
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

Las interacciones genéticas cuantitativas revelan la modularidad biológica.

Pedro Beltrao1, Gerard Cagney, Nevan J Krogan

  • 1Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|June 1, 2010
PubMed
Resumen
Este resumen es generado por máquina.

El mapeo cuantitativo de las interacciones genéticas proporciona una visión a nivel de sistemas de la complejidad biológica. Este enfoque mejora la comprensión de los sistemas biológicos a través de varias escalas.

Más Videos Relacionados

Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

Videos de Experimentos Relacionados

Last Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476
Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

Área de la Ciencia:

  • Biología de sistemas Biología de sistemas.
  • Genética La genética.
  • La bioinformática es la bioinformática.

Sus antecedentes:

  • La investigación biológica tradicional es a menudo reduccionista, centrándose en los componentes individuales.
  • Los avances en la tecnología han llevado a conjuntos de datos biológicos más grandes y completos.
  • Los enfoques de sistemas ofrecen una perspectiva más amplia sobre las interconexiones de los componentes.

Objetivo del estudio:

  • Discutir cómo el mapeo cuantitativo de las interacciones genéticas mejora la comprensión de los sistemas biológicos.
  • Para explorar el interrogatorio de los sistemas biológicos a través de diferentes escalas.

Principales métodos:

  • Cartografía cuantitativa de las interacciones genéticas.
  • Enfoques de la biología de sistemas.
  • Análisis de datos biológicos a gran escala.

Principales resultados:

  • Visión mejorada de los sistemas biológicos a través del mapeo de la interacción genética.
  • Se permite un interrogatorio más profundo de los sistemas biológicos.
  • La comprensión se mejora a través de múltiples escalas biológicas.

Conclusiones:

  • El mapeo cuantitativo de la interacción genética es crucial para la biología de sistemas.
  • Este enfoque facilita una comprensión más holística de los sistemas biológicos complejos.
  • Permite una investigación más profunda a través de diversas escalas biológicas.