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La aceleración de Thorpe-Ingold de la formación de oxirano es en su mayoría un efecto de disolvente

Jakub Kostal1, William L Jorgensen

  • 1Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|June 8, 2010
PubMed
Resumen

La hipótesis de Thorpe-Ingold explica el efecto gem-dimetilo en las reacciones de ciclización. Los estudios computacionales muestran que los efectos del disolvente, no la reactividad intrínseca, impulsan el aumento de la tasa observada con la alfa-metilación.

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