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Efecto de altas dosis de alopurinol en el ejercicio en pacientes con angina crónica estable: un ensayo cruzado
Awsan Noman1, Donald S C Ang, Simon Ogston
1Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Lancet (London, England)
|June 15, 2010
Resumen
Las altas dosis de alopurinol mejoraron significativamente la capacidad de ejercicio y redujeron el dolor en el pecho en pacientes con angina estable. Este inhibidor de la xantina oxidasa es un tratamiento antiisquémico seguro y eficaz.
Área de la Ciencia:
- Cardiología Cardiología.
- Farmacología Farmacología.
Sus antecedentes:
- Los inhibidores de la xantina oxidasa pueden reducir el consumo de oxígeno del miocardio.
- Potencial para el tratamiento de la isquemia en pacientes con angina de pecho.
Objetivo del estudio:
- Para determinar si altas dosis de alopurinol prolongan la capacidad de ejercicio en pacientes con angina crónica estable.
Principales métodos:
- Estudio doble ciego, aleatorizado, controlado con placebo y cruzado.
- 65 pacientes con enfermedad arterial coronaria y angina estable.
- Allopurinol (600 mg/día) o placebo durante 6 semanas, seguido por el cruce.
Principales resultados:
- El alopurinol aumentó significativamente el tiempo hasta la depresión ST (p = 0,0002), el tiempo total de ejercicio (p = 0,0003) y el tiempo hasta el dolor de pecho (p = 0,001).
- No se informaron efectos adversos.
Conclusiones:
- El alopurinol es un medicamento antiisquémico útil, barato, bien tolerado y seguro para pacientes con angina de pecho.
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