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Los niveles séricos de vitamina B y el riesgo de cáncer de pulmón
Mattias Johansson1, Caroline Relton, Per Magne Ueland
1International Agency for Research on Cancer, Lyon, France.
JAMA
|June 17, 2010
Resumen
Los niveles séricos elevados de vitamina B6 y metionina están relacionados con un riesgo reducido de cáncer de pulmón. Estos hallazgos sugieren un papel potencial para estos factores de metabolismo de 1 carbono en la prevención del cáncer de pulmón.
Área de la Ciencia:
- La bioquímica nutricional es una bioquímica nutricional.
- Epidemiología de la epidemiología del cáncer.
- Biología molecular La biología molecular.
Sus antecedentes:
- Las vitaminas B y los factores de metabolismo de 1 carbono son cruciales para la integridad del ADN y la expresión génica.
- Estos factores pueden influir en el riesgo de cáncer, incluido el cáncer de pulmón.
Objetivo del estudio:
- Examinar la asociación entre los factores del metabolismo de 1 carbono y la incidencia del cáncer de pulmón.
- Investigar el papel de las vitaminas B específicas y los metabolitos relacionados en el desarrollo del cáncer de pulmón.
Principales métodos:
- Se utilizaron datos de la cohorte de la Investigación Prospectiva Europea sobre el Cáncer y la Nutrición (EPIC) (n=385.747).
- Se midieron los niveles séricos de vitamina B6, folato, vitamina B12, metionina y homocisteína.
- Se compararon 899 casos de cáncer de pulmón con 1770 controles, analizando las proporciones de probabilidades para el riesgo de cáncer de pulmón basadas en los niveles de metabolitos.
Principales resultados:
- Los niveles séricos más altos de vitamina B6 se asociaron con un riesgo significativamente menor de cáncer de pulmón (OR, 0.44).
- Los niveles elevados de metionina sérica también mostraron una fuerte asociación inversa con el riesgo de cáncer de pulmón (OR, 0.52).
- Los altos niveles combinados de vitamina B6 y metionina redujeron aún más el riesgo de cáncer de pulmón (OR, 0.41).
Conclusiones:
- Los niveles séricos de vitamina B6 y metionina están inversamente asociados con el riesgo de cáncer de pulmón.
- Estos hallazgos ponen de relieve el papel protector potencial de un estado adecuado de vitamina B y metionina contra el cáncer de pulmón.
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