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Propiedades de redes biológicas distintas entre los objetivos de los productos naturales y los genes de enfermedades

Vlado Dancík¹, Kathleen Petri Seiler, Damian W Young

¹Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02143, USA.

Journal of the American Chemical Society

|June 23, 2010

Resumen

Los productos naturales se dirigen efectivamente a proteínas con alta conectividad de red biológica, a diferencia de los genes de enfermedades. Esto sugiere nuevas estrategias para descubrir fármacos que aborden las causas profundas de las enfermedades humanas.

Área de la Ciencia:

La bioquímica es la bioquímica.
Biología de Sistemas Biología de Sistemas.
Farmacología Farmacología.

Sus antecedentes:

Los productos naturales han sido históricamente una rica fuente de compuestos terapéuticos.
Comprender los objetivos moleculares de los productos naturales es crucial para el descubrimiento de fármacos.
Las redes biológicas juegan un papel importante en la patogénesis de las enfermedades.

Objetivo del estudio:

Investigar las propiedades de red de las proteínas diana de los productos naturales.
Para comparar la conectividad de red de objetivos de productos naturales con genes de enfermedades.
Explorar las implicaciones para futuras estrategias de descubrimiento de fármacos.

Principales métodos:

Análisis de las redes de interacción proteína-proteína.
Comparación de métricas de conectividad de red para objetivos de productos naturales y genes de enfermedades.
Análisis bioinformático de las vías biológicas.

Principales resultados:

Los productos naturales se dirigen preferentemente a proteínas con una alta conectividad de red biológica.
Estos objetivos de proteínas exhiben una conectividad de red significativamente mayor que los genes de enfermedades conocidas.
Este mecanismo de orientación puede interrumpir las vías biológicas esenciales, lo que lleva a efectos como la muerte del competidor.

Conclusiones:

La alta conectividad de red de los objetivos de productos naturales sugiere un mecanismo para interrumpir las vías biológicas críticas.
Los futuros esfuerzos de descubrimiento de fármacos deben considerar la orientación de proteínas altamente conectadas para abordar las causas de las enfermedades.
Explorar diversas fuentes de pequeñas moléculas es esencial para identificar nuevas terapias.

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