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El oro (((I) catalizó la cicloadición intermolecular [2+2] cíclica [2+2] de alquinos con alquenos

Verónica López-Carrillo¹, Antonio M Echavarren

¹Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.

Journal of the American Chemical Society

|June 24, 2010

Resumen

Los catalizadores de oro (I) permiten la reacción intermolecular de alquinos y alquenos para formar ciclobutenos. Los complejos de oro catiónico estéricamente obstaculizados son cruciales para esta eficiente síntesis de ciclobuteno.

Área de la Ciencia:

Química orgánica es la química orgánica.
La catálisis de la catálisis.
Química organometálica Química orgánica de los metales.

Sus antecedentes:

La catálisis de oro es un campo de rápido desarrollo en la síntesis orgánica.
La síntesis de ciclobuteno es importante para acceder a los sistemas de anillos tensados.

Objetivo del estudio:

Desarrollar una eficiente reacción intermolecular catalizada por oro entre alquinos y alquenos terminales.
Para investigar el papel de la estructura del catalizador en el logro de altos rendimientos de ciclobutenos.

Principales métodos:

Reacción intermolecular de los alcinos terminales con los alquenos.
Utilizando como catalizadores complejos de oro catiónico estéricamente obstaculizado (I) como catalizadores.

Principales resultados:

La reacción produce con éxito ciclobutenos.
Los catalizadores de oro catiónico estérico obstaculizado (I) son esenciales para el éxito de la reacción.
Se observaron altos rendimientos de productos de ciclobuteno.

Conclusiones:

La catálisis del oro (I) proporciona una ruta efectiva hacia los ciclobutenos.
El diseño del catalizador, específicamente el obstáculo estérico en los complejos de oro catiónico, es crítico para la formación eficiente de ciclobuteno.

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