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La formación in vitro de amiloide a partir de alfa-sinucleína está dominada por las reacciones en las interfaces

Jeremy Pronchik1, Xianglan He, Jason T Giurleo

  • 1Department of Chemistry and Chemical Biology, Wright-Rieman Laboratories, Rutgers, the State University of New Jersey, New Brunswick, 610 Taylor Road, Piscataway, New Jersey 08854, USA.

Journal of the American Chemical Society
|June 29, 2010
PubMed
Resumen

La agitación acelera la alfa-sinucleína (alphaSyn) amiloidogénesis principalmente a través de reacciones de interfaz hidrofóbico-agua, no de transferencia de masa o fragmentación. Este hallazgo requiere reinterpretar los factores que influyen en la propensión a la agregación de alphaSyn.

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