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La regulación espacio-temporal de los genes del ciclo celular por SHORTROOT enlaza el patrón y el crecimiento
R Sozzani1, H Cui, M A Moreno-Risueno
1Department of Biology and IGSP Center for Systems Biology, Duke University, Durham, North Carolina 27708, USA.
Nature
|July 3, 2010
Resumen
El desarrollo de las plantas requiere una división celular controlada. SHORTROOT (SHR) y SCARECROW (SCR) activan directamente una ciclina de tipo D, que regula las divisiones celulares formativas esenciales para el patrón del tejido del suelo de la raíz en Arabidopsis.
Área de la Ciencia:
- Biología del desarrollo vegetal Biología del desarrollo vegetal
- Genética molecular genética molecular.
- Regulación del ciclo celular Regulación del ciclo celular
Sus antecedentes:
- El desarrollo de organismos multicelulares depende de divisiones celulares coordinadas para el crecimiento y el patrón.
- Los mecanismos moleculares de la formación de patrones, especialmente las divisiones celulares formativas, no se comprenden completamente.
- En Arabidopsis, la formación del tejido del suelo de la raíz involucra las proteínas SHORTROOT (SHR) y SCARECROW (SCR).
Objetivo del estudio:
- Aclarar los mecanismos moleculares por los cuales SHR y SCR regulan las divisiones celulares formativas en el desarrollo de la raíz de Arabidopsis.
- Investigar el papel de genes específicos del ciclo celular en la formación de patrones mediados por SHR/SCR.
Principales métodos:
- Perfilamiento transcripcional específico por tipo celular de SHR y SCR.
- Experimentos de microarrays basados en la inmunoprecipitación de cromatina (ChIP-chip).
- Análisis de defectos de división formativa al alterar la expresión de ciclina de tipo D.
Principales resultados:
- SHR y SCR activan directamente genes específicos de división celular de una manera espacial y temporal.
- SHR y SCR activan directamente un gen ciclina de tipo D al inicio de una división formativa clave.
- La modulación de la expresión de ciclina de tipo D conduce a defectos en las divisiones formativas y el patrón de raíz.
Conclusiones:
- La formación de patrones en las plantas se logra a través del control transcripcional preciso de los genes del ciclo celular.
- SHR y SCR vinculan directamente la regulación del desarrollo con la maquinaria del ciclo celular para el patrón de órganos.
- Este estudio revela un mecanismo directo que conecta reguladores del desarrollo, componentes del ciclo celular y patrones de órganos.
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