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SIRT1 suprime la producción de beta-amiloide mediante la activación del gen alfa-secretasa ADAM10

Gizem Donmez1, Diana Wang, Dena E Cohen

  • 1Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|July 27, 2010
PubMed
Resumen

La sobreexpresión de SIRT1 en el cerebro reduce las placas beta-amiloides en los modelos de la enfermedad de Alzheimer (EA). La activación de SIRT1 es una estrategia potencial para el tratamiento de la EA y otras enfermedades neurodegenerativas.

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