Video Experimental Relacionado
Updated: Jun 10, 2026
07:04
Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche
Published on: July 20, 2015
Los orígenes tempranos de los cordones de los vertebrados en el segundo campo del corazón de los vertebrados
Alberto Stolfi1, T Blair Gainous, John J Young
1Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Science (New York, N.Y.)
|July 31, 2010
Resumen
El estudio revela que las células progenitoras simples del corazón cordado forman precursores de los músculos del sifón auricular, compartiendo la expresión génica con los progenitores del segundo campo cardíaco (SHF) de los vertebrados. Esto sugiere un origen evolutivo compartido para los músculos cardiofaríngeos.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología del desarrollo evolutivo Biología del desarrollo evolutivo
- Embriología de cordados.
Sus antecedentes:
- El corazón de los vertebrados se desarrolla a partir de distintas regiones embrionarias, incluyendo el primer y segundo campos cardíacos (SHF).
- El SHF es crucial para la formación del ventrículo derecho y el tracto de salida, pero su historia evolutiva sigue siendo en gran medida desconocida.
Objetivo del estudio:
- Investigar los orígenes evolutivos del segundo campo cardíaco (SHF).
- Identificar vías de desarrollo homólogas en cordados más simples que puedan arrojar luz sobre la evolución del corazón de los vertebrados.
Principales métodos:
- Embriología comparativa utilizando el cordado simple Ciona intestinalis.
- Análisis de los patrones de expresión génica en las células progenitoras del corazón.
- Investigando el papel de los factores de transcripción como el COE.
Principales resultados:
- Las células progenitoras del corazón en Ciona intestinalis generan precursores para los músculos del sifón auricular (ASM).
- Estos precursores exhiben una expresión génica (Islet, Tbx1/10) similar a la del mesodermo esplancánico de los vertebrados y a la SHF.
- El factor de transcripción COE es identificado como un regulador clave del destino de la ASM.
Conclusiones:
- Propone que los precursores multipotentes del músculo cardiofaríngeo existieron en el último antepasado común de los tunicados y vertebrados.
- Sugiere que la reasignación de estos precursores puede haber sido instrumental en la evolución de los vertebrados SHF.
Videos de Conceptos Relacionados
01:27Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
01:16Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
01:07Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
01:27Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
01:20Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
01:15Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...