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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Desimetrización hidrogenativa altamente enantioselectiva de las imidas bicíclicas que conduce a compuestos cíclicos

Masato Ito1, Chika Kobayashi, Akio Himizu

  • 1Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.

Journal of the American Chemical Society
|August 3, 2010
PubMed
Resumen

Los catalizadores quirales permiten una hidrogenación altamente enantioselectiva de las imidas bicíclicas. Este método produce directamente compuestos cíclicos definidos estereoquímicamente con un excelente exceso enantiomérico, simplificando la síntesis.

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