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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
10:28

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay

Published on: January 8, 2012

La enfermedad trofoblástica gestacional.

Michael J Seckl1, Neil J Sebire, Ross S Berkowitz

  • 1Department of Cancer Medicine, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College London, London, UK. m.seckl@imperial.ac.uk

Lancet (London, England)
|August 3, 2010
PubMed
Resumen
Este resumen es generado por máquina.

El manejo de la enfermedad trofoblástica gestacional (GTD) ha avanzado significativamente, logrando más del 98% de tasas de curación para las formas malignas. Los tratamientos efectivos, el uso de biomarcadores y la atención centralizada han mejorado dramáticamente los resultados para las mujeres con estos tumores raros.

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Área de la Ciencia:

  • Ginecología Ginecología.
  • Oncología Oncología.
  • La Medicina Reproductiva es una de ellas.

Sus antecedentes:

  • La enfermedad trofoblástica gestacional (GTD) incluye moles hidatidiformes premalignados y tumores GT malignos como el coriocarcinoma.
  • Históricamente, la GTD maligna tenía altas tasas de mortalidad.

Objetivo del estudio:

  • Para resumir las estrategias de gestión actuales para GTD.
  • Para discutir controversias y futuras investigaciones en GTD.

Principales métodos:

  • Revisión de los protocolos de gestión y seguimiento para GTD.
  • Análisis de los factores que contribuyen a mejorar las tasas de curación.

Principales resultados:

  • Los protocolos de manejo actuales logran más del 98% de tasas de curación para GTD.
  • Los tratamientos efectivos, la gonadotropina coriónica humana (hCG) como biomarcador y la atención centralizada son la clave para el éxito.

Conclusiones:

  • El manejo moderno ha transformado los resultados de la GTD, permitiendo altas tasas de curación y preservación de la fertilidad.
  • La investigación continua y la atención centralizada son vitales para futuros avances.