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Protein Organization01:13

Protein Organization

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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Predicción de estructuras de proteínas con un juego multijugador en línea.

Seth Cooper1, Firas Khatib, Adrien Treuille

  • 1Department of Computer Science and Engineering, University of Washington, Box 352350, Seattle, Washington 98195, USA.

Nature
|August 6, 2010
PubMed
Resumen
Este resumen es generado por máquina.

Los juegos en línea pueden resolver problemas científicos complejos. Foldit, un juego de predicción de la estructura de proteínas, utiliza la resolución de problemas humanos y el desarrollo de estrategias para encontrar soluciones con las que los métodos tradicionales luchan.

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Área de la Ciencia:

  • Biología computacional Biología computacional.
  • La biofísica es la biofísica.
  • Biología estructural Biología estructural.

Sus antecedentes:

  • El crowdsourcing de problemas científicos a través de juegos ha tenido éxito para tareas simples.
  • Los desafíos científicos complejos, como la predicción de la estructura de las proteínas, siguen siendo computacionalmente intensivos.
  • Localizar la conformación nativa de una proteína es difícil debido a los vastos espacios de búsqueda.

Objetivo del estudio:

  • Para presentar Foldit, un juego multijugador en línea para no científicos para resolver problemas de predicción de la estructura de las proteínas.
  • Investigar si la computación dirigida por humanos a través de juegos puede abordar desafíos científicos complejos.
  • Para explorar el potencial de la integración de la resolución de problemas humanos con algoritmos computacionales.

Principales métodos:

  • Desarrolló Foldit, un juego multijugador en línea que utiliza algoritmos de Rosetta para la predicción de la estructura de las proteínas.
  • Invitó a no científicos a interactuar con las estructuras de proteínas utilizando herramientas de manipulación directa.
  • Permitió a los jugadores competir y colaborar para optimizar los cálculos de energía de las proteínas.

Principales resultados:

  • Los mejores jugadores de Foldit demostraron competencia en la resolución de problemas difíciles de refinamiento de la estructura de proteínas.
  • El juego colaborativo condujo al desarrollo de nuevas estrategias y algoritmos por parte de los jugadores.
  • Los jugadores exploraron los espacios de estrategia de conformación y búsqueda, superando los enfoques puramente computacionales.

Conclusiones:

  • Los juegos multijugador interactivos pueden integrar eficazmente la resolución de problemas visuales humanos con algoritmos computacionales.
  • Foldit representa un nuevo y poderoso enfoque para abordar problemas científicos limitados por la computación.
  • La computación dirigida por humanos a través de juegos ofrece una estrategia viable para avanzar en el descubrimiento científico.