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In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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Deamidación de glutamina y disfunción de la ubiquitina/NEDD8 inducida por una familia de efectores bacterianos

Jixin Cui1, Qing Yao, Shan Li

  • 1Graduate Program in Chinese Academy of Medical Sciences and Beijing Union Medical College, Beijing 100730, China.

Science (New York, N.Y.)
|August 7, 2010
PubMed
Resumen

Las proteínas bacterianas CHBP y Cif inhiben la vía de ubiquitinación desamidando la ubiquitina y la NEDD8. Esta desamidation perjudica la síntesis de la cadena de la ubiquitina y la actividad de la ligasa del CRL, afectando el ciclo celular y las estructuras de la actina.

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