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Las células madre y el daño al ADN: ¿persisten o perecen?
Andrew A Lane1, David T Scadden
1Center for Regenerative Medicine, Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA. aalane@partners.org
Cell
|August 10, 2010
Resumen
Las células madre hematopoyéticas (HSC) se enfrentan a riesgos de daño al ADN. Los HSCs de ratón y humanos exhiben respuestas opuestas, eligiendo morir o persistir después del daño al ADN.
Área de la Ciencia:
- Biología de las células madre Biología de las células madre
- La hematopoyesis es la hematopoyesis.
- Respuesta al daño del ADN en respuesta al daño del ADN.
Sus antecedentes:
- Las células madre poseen capacidad de autorrenovación y repoblación de tejidos.
- Estas funciones esenciales hacen que las células madre sean susceptibles al daño genotóxico.
- Comprender las decisiones del destino de las células madre después del daño del ADN es crucial para la medicina regenerativa.
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