Video Experimental Relacionado
Updated: May 5, 2026
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.0K
Capacidad de ejercicio y mortalidad en hombres mayores: un estudio de seguimiento de 20 años
Peter Kokkinos1, Jonathan Myers, Charles Faselis
1Cardiology Division, Veterans Affairs Medical Center, 50 Irving St NW, Washington, DC 20422, USA. peter.kokkinos@med.va.gov
Circulation
|August 11, 2010
Resumen
Una mayor capacidad de ejercicio reduce significativamente el riesgo de mortalidad en hombres mayores. Mejorar la condición física, incluso desde niveles no aptos, proporciona beneficios sustanciales de supervivencia.
Área de la Ciencia:
- Gerontología Gerontología.
- Salud Cardiovascular La salud cardiovascular.
- La medicina preventiva es la medicina preventiva de las enfermedades.
Sus antecedentes:
- Los datos epidemiológicos existentes sobre la capacidad de ejercicio y la mortalidad involucran principalmente a poblaciones de mediana edad.
- Se dispone de información limitada con respecto a esta asociación en personas mayores.
Objetivo del estudio:
- Investigar la asociación entre la capacidad de ejercicio y la mortalidad por cualquier causa en hombres mayores.
- Determinar si la capacidad de ejercicio es un predictor independiente de la mortalidad en este grupo demográfico.
Principales métodos:
- Una cohorte de 5314 veteranos varones de 65 a 92 años de edad se sometieron a pruebas de ejercicio entre 1986 y 2008.
- El estado físico se clasificó por los equivalentes metabólicos máximos (MET) alcanzados.
- El riesgo de mortalidad se evaluó durante un seguimiento mediano de 8,1 años.
Principales resultados:
- La capacidad de ejercicio predijo fuertemente la mortalidad; cada aumento de 1-MET redujo el riesgo de muerte en un 12%.
- Los individuos que lograron >5 METs tenían un riesgo de mortalidad significativamente menor en comparación con los menos aptos (<4 METs).
- La mejora del estado físico se asoció con una reducción del 35% en el riesgo de mortalidad.
Conclusiones:
- La capacidad de ejercicio es un predictor independiente y graduado de la mortalidad por todas las causas en los hombres mayores.
- Los beneficios de supervivencia son más pronunciados con la capacidad de ejercicio superior a 5 METs.
- La mejora de la condición física en individuos previamente no aptos conduce a ganancias significativas de supervivencia.
Videos de Conceptos Relacionados
02:20Longitudinal Research
11.7K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.7K
01:19The Effect of Aging on Tissues
3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
01:17Exercise and Cardiac Output
4.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
4.0K
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
405
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
405
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
358
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
358
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
376
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
376