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Updated: Jun 10, 2026

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

La activación de caspasas apoptóticas específicas con una proteasa activada por moléculas pequeñas de ingeniería

Daniel C Gray1, Sami Mahrus, James A Wells

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|August 21, 2010
PubMed
Resumen

Los investigadores desarrollaron un nuevo método para activar selectivamente las caspasas, revelando que la activación de la caspasa-3 o -7 induce la apoptosis. También encontraron que las caspasas dividen subunidades proteasómicas, lo que sugiere terapias combinadas para el tratamiento del cáncer.

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