Video Experimental Relacionado
Updated: Jun 9, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Filariasis linfática y oncocerciasis
Mark J Taylor1, Achim Hoerauf, Moses Bockarie
1Liverpool School of Tropical Medicine, Liverpool, UK. mark.taylor@liv.ac.uk
Lancet (London, England)
|August 27, 2010
Resumen
La filariasis linfática y la oncocercosis son enfermedades parasitarias tropicales que afectan a la salud pública. La doxiciclina y otros fármacos, dirigidos a las bacterias Wolbachia simbióticas, son prometedores en el tratamiento de estas infecciones debilitantes por helmintos.
Área de la Ciencia:
- Parasitología Parasitología.
- La Medicina Tropical es una medicina tropical.
- Salud Pública La salud pública.
Sus antecedentes:
- La filariasis linfática y la oncocercosis son las principales enfermedades parasitarias tropicales causadas por nematodos filariales.
- Estas infecciones conducen a enfermedades crónicas como linfedema, elefantiasis, enfermedades de la piel y ceguera.
- Los nematodos filariales dependen de las bacterias Wolbachia simbióticas para la supervivencia y la patogénesis.
Objetivo del estudio:
- Revisar la patogénesis y el tratamiento de la filariasis linfática y la oncocercosis.
- Para resaltar el papel de las bacterias Wolbachia en la enfermedad y como objetivo terapéutico.
- Para discutir los tratamientos actuales de drogas y las estrategias globales de control.
Principales métodos:
- Revisión de la literatura científica sobre las enfermedades filariales y su tratamiento.
- Análisis del papel de los endosimbiontes de Wolbachia en la biología y patogénesis de los nematodos.
- Resumen de las terapias farmacológicas actuales que incluyen doxiciclina, dietilcarbamazina, ivermectina y albendazol.
Principales resultados:
- Las bacterias Wolbachia son esenciales para la supervivencia de los nematodos filariales y contribuyen a la patología inflamatoria.
- La terapia con doxiciclina se dirige a Wolbachia, demostrando actividad macrofilaricida y mejorando los resultados.
- Las terapias de combinación con dietilcarbamazina, ivermectina y albendazol se utilizan para reducir las microfilarias.
Conclusiones:
- La terapia dirigida a Wolbachia, particularmente con doxiciclina, ofrece un enfoque prometedor para el tratamiento de la filariasis linfática y la oncocercosis.
- La entrega sostenida de medicamentos a través de programas globales es crucial para interrumpir la transmisión y eliminar estas enfermedades.
- Las estrategias integradas de tratamiento son esenciales para gestionar la carga de salud pública de estas enfermedades tropicales descuidadas.
Videos de Conceptos Relacionados
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:22American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
01:15Anthelminthic Agents
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:28Fungal Phylum Microsporidia
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...