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Síntesis total asimétrica de la vindorosina, la vindolina y los principales análogos de la vinblastina

Yoshikazu Sasaki1, Daisuke Kato, Dale L Boger

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|September 3, 2010
PubMed
Resumen

Las síntesis concisas de vindolina y vindorosina se lograron utilizando una nueva cascada de cicloadición. Este método estableció de manera eficiente los principales estereocentros y características estructurales, lo que permitió la creación de nuevos análogos para estudios biológicos.

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