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Updated: Jun 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Bases estructurales para la inhibición alosterica cíclica de la poliamida Py-Im en la unión al receptor nuclear

David M Chenoweth1, Peter B Dervan

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|September 4, 2010
PubMed
Resumen

Las poliamidas pirrol-imidazol son moléculas programables que se unen al ADN y alteran la expresión génica. Una nueva estructura cristalina muestra cómo estas poliamidas cíclicas interrumpen la unión del factor de transcripción cambiando la forma del ADN.

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