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La señalización de la fosfotirosina: la evolución de un nuevo sistema de comunicación celular
1Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. lim@cmp.ucsf.edu
Cell
|September 4, 2010
Resumen
La evolución de la fosforilación de la tirosina, un proceso celular clave, involucró un conjunto de herramientas de cinasas de tirosina, fosfatasas y dominios SH2. El análisis genómico revela este sistema.
Área de la Ciencia:
- La señalización celular de las células.
- Biología molecular La biología molecular.
- Biología evolutiva Biología evolutiva.
Sus antecedentes:
- La fosforilación de la tirosina es crucial para numerosas funciones celulares.
- El conjunto de herramientas reguladoras incluye las tirosinacinasas, las fosfotirosinafosfatasas y los dominios Src Homología 2 (SH2).
- Este sistema de señalización es una innovación evolutiva reciente.
Objetivo del estudio:
- Para investigar los orígenes evolutivos del sistema de señalización de la fosfotirosina.
- Para entender por qué este sistema rápidamente se convirtió en esencial para los metazoos.
Principales métodos:
- Se emplearon análisis genómicos para estudiar la historia evolutiva.
- Es probable que se hayan utilizado enfoques genómicos comparativos para rastrear el origen del kit de herramientas.
Principales resultados:
- El conjunto de herramientas para la señalización de la fosfotirosina es un desarrollo evolutivo relativamente nuevo.
- Los datos genómicos proporcionan información sobre el surgimiento del sistema.
Conclusiones:
- El sistema de señalización de la fosfotirosina, que comprende las quinasas, las fosfatasas y los dominios SH2, se originó relativamente recientemente en la historia evolutiva.
- Su rápida adopción pone de relieve su importancia crítica para la vida de los metazoos.
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