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Invasion of Human Cells by a Bacterial Pathogen
Published on: March 21, 2011
Los patógenos bacterianos restringidos en humanos bloquean el derramamiento de células epiteliales al estimular la
Petra Muenzner1, Verena Bachmann, Wolfgang Zimmermann
1Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, 78457 Konstanz, Germany.
Science (New York, N.Y.)
|September 4, 2010
Resumen
Las bacterias patógenas utilizan la unión al antígeno carcinoembrionario (CEA) para suprimir el derramamiento de células epiteliales, lo que permite la colonización. Este mecanismo implica la transformación del receptor del factor de crecimiento CD105 y la activación de la integrina beta1, ofreciendo objetivos terapéuticos potenciales.
Área de la Ciencia:
- Microbiología Microbiología.
- Biología celular Biología celular.
- Inmunología Inmunología.
Sus antecedentes:
- Las infecciones bacterianas a menudo comienzan con la colonización de patógenos en las superficies de la mucosa.
- El derramamiento de células epiteliales (exfoliación) es un mecanismo de defensa de la mucosa protectora.
- Las estrategias empleadas por los patógenos para superar la exfoliación no se comprenden bien.
Objetivo del estudio:
- Para investigar cómo las bacterias contrarrestan la exfoliación de la mucosa para la colonización.
- Aclarar los mecanismos moleculares por los cuales las bacterias que se unen al CEA logran la colonización de la mucosa.
Principales métodos:
- Utilizó ratones transgénicos CEA y ratones de tipo salvaje para estudiar la colonización bacteriana.
- Se analizó la expresión del receptor transformador del factor de crecimiento CD105.
- Cambios investigados en la composición de la adhesión focal y la activación de la integrina beta1.
Principales resultados:
- Las bacterias que se unen al CEA colonizaron el tracto urogenital de los ratones transgénicos CEA, pero no de los ratones de tipo salvaje.
- La unión a CEA suprimió la exfoliación de las células de la mucosa.
- La unión de CEA indujo la expresión de novo de CD105, alteró las adherencias focales y activó las integrinas beta1.
Conclusiones:
- Las bacterias que se unen al CEA suprimen la exfoliación de la mucosa al manipular las vías de señalización de las células huésped.
- El mecanismo observado que involucra a las integrinas CD105 y beta1 es crucial para una eficiente colonización de la mucosa.
- Dirigirse a esta manipulación bacteriana de la señalización de la integrina presenta una estrategia potencial para prevenir o tratar las infecciones.
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