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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Marcos homoquirales metal-orgánicos para la catálisis asimétrica heterogénea
Dongbin Dang1, Pengyan Wu, Cheng He
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, China.
Journal of the American Chemical Society
|October 1, 2010
Resumen
Las estructuras quirales metal-orgánicas (MOF) fueron sintetizadas utilizando inductores quirales específicos. Estos MOFs homoquirales demuestran una alta enantioselectividad en la catalización de reacciones asimétricas de cianosilación y Aldol.
Área de la Ciencia:
- Química de los materiales Química de los materiales
- La catálisis de la catálisis.
- La cristalografía es una técnica de cristalografía.
Sus antecedentes:
- Las estructuras quirales metal-orgánicas (MOF) son cruciales para la síntesis asimétrica.
- El control de la enantioselectividad en la catálisis de MOF sigue siendo un desafío significativo.
Objetivo del estudio:
- Para lograr la cristalización homoquiral de los MOFs enantioméricos utilizando inductores quirales.
- Investigar la actividad catalítica y la enantioselectividad de estos MOF homoquirales en reacciones asimétricas.
Principales métodos:
- La cristalización homoquiral de las MOF (Ce-MDIP1 y Ce-MDIP2) utilizando L- o D-BCIP como inductores quirales.
- Caracterización de la quiralidad de MOF utilizando espectros de dicroísmo circular (CD) en estado sólido.
- Evaluación del rendimiento catalítico en la cianosiliación asimétrica de aldehídos aromáticos y reacciones de Aldol.
Principales resultados:
- Síntesis exitosa de MOFs homoquiral, Ce-MDIP1 y Ce-MDIP2, con quiralidad confirmada a través de espectros de CD.
- Los Ce-MDIPs exhibieron una excelente actividad catalítica y una alta enantioselectividad en la cianosilización asimétrica de aldehídos aromáticos.
- Un MOF homoquiral separado Cd-TBT MOF con L-PYI demostró la catálisis estereoquímica en las reacciones de Aldol.
Conclusiones:
- Los MOFs homoquirales pueden sintetizarse eficazmente utilizando inductores quirales.
- Estos MOF muestran un potencial significativo como catalizadores para la síntesis enantioselectiva, particularmente en las reacciones de cianosilación y Aldol.
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