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Traducir la investigación del cáncer en terapias dirigidas
1The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK. johann.de-bono@icr.ac.uk
Nature
|October 1, 2010
Resumen
El desarrollo de fármacos contra el cáncer está cambiando hacia terapias dirigidas, pero sigue siendo lento. El progreso futuro depende de la investigación integrada y los ensayos clínicos basados en biomarcadores para la medicina personalizada.
Área de la Ciencia:
- Oncología Oncología.
- Farmacología Farmacología.
- Biotecnología La biotecnología es la biotecnología.
Sus antecedentes:
- La quimioterapia tradicional está siendo reemplazada por medicamentos dirigidos contra el cáncer.
- A pesar de los avances, el desarrollo de fármacos contra el cáncer es un proceso largo e ineficiente.
Objetivo del estudio:
- Para identificar los desafíos en el desarrollo actual de fármacos contra el cáncer.
- Proponer estrategias para mejorar y acelerar el proceso de desarrollo de fármacos.
Principales métodos:
- Revisión de las tendencias actuales en el desarrollo de fármacos contra el cáncer.
- Análisis de los problemas que obstaculizan el proceso.
- Propuesta de investigación integrada y diseños de ensayos clínicos adaptativos.
Principales resultados:
- El cambio hacia fármacos dirigidos molecularmente muestra una promesa de eficacia y efectos secundarios reducidos.
- Persisten retrasos significativos en el suministro de nuevos medicamentos contra el cáncer a los pacientes.
Conclusiones:
- La investigación integrada del cáncer y los ensayos adaptativos basados en biomarcadores son cruciales.
- La medicina personalizada del cáncer requiere una comprensión profunda de la genética y la biología del paciente y del tumor.
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