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Genetic Modification and Recombination of Salivary Gland Organ Cultures
Published on: January 28, 2013
La inervación parasimpática mantiene las células epiteliales progenitoras durante la organogénesis salival
S M Knox1, I M A Lombaert, X Reed
1Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA.
Science (New York, N.Y.)
|October 9, 2010
Resumen
Los nervios parasimpáticos mantienen las células epiteliales progenitoras para el desarrollo de órganos utilizando la señalización de acetilcolina. Esta vía, que involucra a los receptores M1 y del factor de crecimiento epidérmico, es crucial para la organogénesis y puede ayudar en la reparación.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
- La neurociencia es la neurociencia.
Sus antecedentes:
- El mantenimiento de las células progenitoras es vital para el desarrollo y la regeneración de los órganos.
- Los mecanismos de regulación de las células progenitoras epiteliales durante la organogénesis no se comprenden completamente.
Objetivo del estudio:
- Investigar el papel de la inervación parasimpática en el mantenimiento de las células epiteliales progenitoras durante la organogénesis.
- Para aclarar las vías de señalización involucradas en este proceso.
Principales métodos:
- El cultivo de órganos explantados en ratones se utilizó para estudiar las células epiteliales progenitoras.
- Se extirparon los ganglios parasimpáticos y se evaluaron los efectos con y sin tratamiento análogo a la acetilcolina.
- Se analizaron las vías de expresión y señalización, incluidos los receptores muscarínicos M1 y el factor de crecimiento epidérmico.
Principales resultados:
- La eliminación de los ganglios parasimpáticos redujo el número y alteró la morfogénesis de las células progenitoras epiteliales queratina 5-positivas.
- El tratamiento con análogos de acetilcolina rescató estos efectos, lo que indica un papel protector.
- La señalización de acetilcolina, mediada por los receptores M1 y del factor de crecimiento epidérmico, promovió la morfogénesis epitelial y la proliferación de células progenitoras.
Conclusiones:
- La inervación parasimpática es esencial para mantener la población de células epiteliales progenitoras en un estado indiferenciado durante la organogénesis.
- Este mecanismo es crítico para el desarrollo adecuado de los órganos.
- Dirigirse a esta vía mediada por acetilcolina tiene potencial para las estrategias de reparación y regeneración de órganos.
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