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Ciclización de una dipentaenona celular por Streptomyces coelicolor citocromo P450 154A1 sin oxidación/reducción

Qian Cheng1, David C Lamb, Steven L Kelly

  • 1Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University, School of Medicine, Nashville Tennessee 37232-0146, USA.

Journal of the American Chemical Society
|October 29, 2010
PubMed
Resumen

Streptomyces coelicolor citocromo P450 154A1 es crucial para la estabilidad de las esporas. Esta enzima cataliza una inusual ciclización intramolecular de un nuevo sustrato de dipentaenona, formando un producto parecido a Paternò-Büchi.

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