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La aminosulfonilación catalizada por el paladio de haluros de arilo catalizada por el paladio

Bao Nguyen¹, Edward J Emmett, Michael C Willis

¹Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

Journal of the American Chemical Society

|October 30, 2010

Resumen

Una nueva reacción catalizada por el paladio sintetiza de manera eficiente las N-aminosulfonamidas de arilo a partir de yoduros de arilo e hidrazinas utilizando dióxido de azufre. Este acoplamiento de tres componentes ofrece un método versátil para crear estos importantes compuestos químicos.

Área de la Ciencia:

Química orgánica es la química orgánica.
La catálisis de la catálisis.
Metodología sintética de la metodología sintética.

Sus antecedentes:

Las N-aminosulfonamidas de arilo son valiosos motivos estructurales en la química medicinal.
Las rutas sintéticas eficientes para estos compuestos son muy buscadas.

Objetivo del estudio:

Desarrollar una nueva reacción de acoplamiento de tres componentes catalizada por paladio.
Para sintetizar las N-aminosulfonamidas de arilo utilizando materiales de partida fácilmente disponibles.

Principales métodos:

El acoplamiento catalizado por paladio de yoduros de arilo, dióxido de azufre e hidrazinas.
Utilizado DABCO·(SO(2))(2) como una fuente conveniente de dióxido de azufre.

Principales resultados:

Con éxito sintetizó una gama de N-aminosulfonamidas de arilo.
La reacción demostró tolerancia a diversos sustratos de yoduro de arilo e hidrazina.
Se logró un acoplamiento eficiente de tres componentes en condiciones suaves.

Conclusiones:

La reacción catalizada por paladio desarrollada proporciona una ruta fácil y versátil a las N-aminosulfonamidas de arilo.
Este método ofrece un enfoque práctico para acceder a diversos derivados de sulfonamidas.

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