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Updated: Jun 7, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
11:28

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates

Published on: March 31, 2012

La degradación mediada por EphB de la RhoA GEF Ephexin5 alivia un freno del desarrollo en la formación de sinapsis

Seth S Margolis1, John Salogiannis, David M Lipton

  • 1Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|October 30, 2010
PubMed
Resumen

Los investigadores encontraron que Ephexin5 limita el desarrollo de la sinapsis excitatoria. Su degradación, desencadenada por la señalización de EphrinB / EphB y mediada por Ube3A, promueve la formación de sinapsis, impactando potencialmente en trastornos cognitivos como el síndrome de Angelman y los trastornos del espectro autista.

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