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Las propiedades y los rompecabezas de la paramutación.

Vicki L Chandler¹

¹BIO5 Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85719, USA. chandler@ag.arizona.edu

Science (New York, N.Y.)

|October 30, 2010

Resumen

Este resumen es generado por máquina.

La paramutación es un proceso en el que las secuencias de ADN establecen estados hereditarios de expresión génica. Se supone que los estados específicos de la cromatina subyacen a este fenómeno epigenético, que involucra repeticiones no codificantes y silenciamiento dirigido por ARN.

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Área de la Ciencia:

Genética La genética.
La epigenética es la epigenética.
Biología Molecular Biología Molecular

Sus antecedentes:

La paramutación implica secuencias de ADN homólogas que se comunican en trans para establecer estados de expresión hereditarios.
Los mecanismos moleculares subyacentes de la paramutación siguen siendo en gran medida desconocidos.
Las hipótesis actuales sugieren que los estados específicos de la cromatina se establecen y se transmiten durante la paramutación.

Objetivo del estudio:

Para investigar las bases moleculares de las paramutaciones.
Para identificar las moléculas específicas que median el silenciamiento hereditario durante la paramutación.

Principales métodos:

Análisis de las repeticiones en tándem transcritas y no codificadas.
Investigando proteínas implicadas en el silenciamiento transcripcional dirigido por ARN en plantas y levaduras.

Principales resultados:

La paramutación requiere repeticiones en tándem transcritas y no codificadas.
Las proteínas involucradas en el silenciamiento transcripcional dirigido por ARN son necesarias para la paramutación.

Conclusiones:

La paramutación implica mecanismos epigenéticos, probablemente mediados por los estados de la cromatina.
Se necesita más investigación para determinar las moléculas precisas responsables del silenciamiento hereditario en la paramutación.